Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural occurrence and origin of somatically mutated memory B cells in mice.

The Journal of experimental medicine - 1 Aug 1992

Schittek B, Rajewsky K

Abstract excerpt

While most murine peripheral B cells express germline-encoded antibodies of classes M and D (mu+ delta+ cells), small numbers of memory B cells expressing somatically mutated immunoglobulin G antibodies are generated upon T cell-dependent immunization. Analyzing the antibody repertoire of the mu-delta- B cell pool in unimmunized mice, we show that these cells express somatically mutated VH genes and that most of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 1500855
DOI: 10.1084/jem.176.2.427
PMCID: PMC2119338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural occurrence and origin of somatically mutated memory B cells in mice.PMID 1500855Read ↗

The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age.Semantic proximity Read ↗

T cell-independent somatic hypermutation in murine B cells with an immature phenotype.Semantic proximity Read ↗

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memorySemantic proximity Read ↗

Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes.Semantic proximity Read ↗

Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro.Semantic proximity Read ↗

VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.Semantic proximity Read ↗

The role of somatic hypermutation in the generation of pathogenic antibodies in SLESemantic proximity Read ↗

The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strainsSemantic proximity Read ↗

Prevalent de novo somatic mutations in superantigen genes of mouse mammary tumor viruses in the genome of C57BL/6J mice and its potential implication in the immune system.Semantic proximity Read ↗

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.Semantic proximity Read ↗

Insufficiency of Genomic Structure in Immunoglobulin Locus for Inducing High-Frequency Gene Conversion in Variable RegionsSemantic proximity Read ↗

Class-switched marginal zone B cells in spleen have relatively low numbers of somatic mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.