Article
Natural occurrence and origin of somatically mutated memory B cells in mice.
The Journal of experimental medicine - 1 Aug 1992
Schittek B, Rajewsky K
Abstract excerpt
While most murine peripheral B cells express germline-encoded antibodies of classes M and D (mu+ delta+ cells), small numbers of memory B cells expressing somatically mutated immunoglobulin G antibodies are generated upon T cell-dependent immunization. Analyzing the antibody repertoire of the mu-...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- B-Lymphocytes
- Base Sequence
- Clone Cells
- DNA
- Female
- Flow Cytometry
- Immunoglobulin Variable Region
- Immunologic Memory
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Sequence Alignment