Article
VH genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis.
Clinical and experimental immunology - 1 Mar 1997
Tilgner J, Golembowski S, Kersten B, Sterry W, Jahn S
Abstract excerpt
In this study we analysed the VH genes expressed in IgE-producing peripheral B cells in two patients with severe atopic dermatitis. We found a diverse antibody repertoire containing V(H) genes of five different VH families, no VH2 and 7 genes, with no biased usage of one particular VH gene family...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Dermatitis, Atopic
- Gene Amplification
- Gene Expression Regulation
- Gene Frequency
- Genes, Immunoglobulin
- Humans
- Immunoglobulin E
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Male
- Molecular Sequence Data
- Multigene Family
- Mutation