Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction

1 Jul 1995

Abstract excerpt

The VH gene repertoire of human peripheral B cells was analyzed using PCR analysis of individual blood B cells. Because genomic DNA of single B cells was analyzed, data from both productive and nonproductive VDJ rearrangements were obtained. Nine out of 75 B cells contained both functional and nonfunctional rearrangement products, whereas 62/75 had a single productive VDJ rearrangement. The distribution of VH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Immunodeficiency and Autoimmune Disorders
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7602095
DOI: 10.4049/jimmunol.155.1.190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reactionPMID 7602095Read ↗

Molecular Mechanisms and Selection Influence the Generation of the Human VλJλ RepertoireSemantic proximity Read ↗

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements.Semantic proximity Read ↗

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the humanSemantic proximity Read ↗

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human.Semantic proximity Read ↗

Representation of rearranged VH gene segments in the human adult antibody repertoire.Semantic proximity Read ↗

Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.Semantic proximity Read ↗

Bovine IgG repertoire is dominated by a single diversified VH gene familySemantic proximity Read ↗

Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement.Semantic proximity Read ↗

Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus.Semantic proximity Read ↗

Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.