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Article

Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation.

Blood - 1 Aug 1992

Stiernholm N, Kuzniar B, Berinstein N L

Abstract excerpt

Several genetic mechanisms have been shown to diversity the expressed antibody repertoire of committed B lymphocytes. These include somatic hypermutation, V gene replacement, and ongoing gene rearrangement. These mechanisms may be operational at discrete points in the B-cell differentiation pathway and may generate idiotypic diversity in various malignant B-cell tumors. Hypermutation of the Ig variable region has...

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PMID: 1638025

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Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation.PMID 1638025Read ↗

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