Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation.

Blood - 1 Aug 1992

Stiernholm N, Kuzniar B, Berinstein N L

Abstract excerpt

Several genetic mechanisms have been shown to diversity the expressed antibody repertoire of committed B lymphocytes. These include somatic hypermutation, V gene replacement, and ongoing gene rearrangement. These mechanisms may be operational at discrete points in the B-cell differentiation pathway and may generate idiotypic diversity in various malignant B-cell tumors. Hypermutation of the Ig variable region has...

Topics

Base Sequence
Blotting, Southern
Cell Line
Clone Cells
DNA, Neoplasm
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Lymphoma, Large B-Cell, Diffuse
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

RNA, Neoplasm

Source

Identifiers

PMID: 1638025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1638025-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation.PMID 1638025Read ↗

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.Semantic proximity Read ↗

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.Semantic proximity Read ↗

The occurrence and significance of V gene mutations in B cell-derived human malignancy.Semantic proximity Read ↗

Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.Semantic proximity Read ↗

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.Semantic proximity Read ↗

Conserved patterns of somatic mutation and secondary VH gene rearrangement create aberrant Ig-encoding genes in Epstein-Barr virus-transformed and normal human B lymphocytes.Semantic proximity Read ↗

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.Semantic proximity Read ↗

Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells.Semantic proximity Read ↗

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.Semantic proximity Read ↗

Novel secondary Ig VH gene rearrangement and in-frame Ig heavy chain complementarity-determining region III insertion/deletion variants in de novo follicular lymphoma.Semantic proximity Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.