Article
VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1997
Cascalho M, Wong J, Wabl M
Abstract excerpt
The primary repertoire of the quasimonoclonal mouse is monospecific. However, among peripheral B cells, there is a high frequency of variant cells with V(H) replacements, which are also hypermutated. We show in this work that these hyperselected cells expand in numbers as the animals increase in age, switch their isotypes, and with increasing age become the almost exclusive contributors to the pool of serum Ig....
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