A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies.

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Article

A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1993

Huang C, Stollar B D

Abstract excerpt

Certain Ig VH gene segments, with few or no mutations, recur frequently in natural autoantibodies, fetal antibodies, and products of B cell tumors. The goal of this study was to determine whether similar Ig gene segment usage occurs in normal human adult PBL. Extending previous analyses, 105 rand...

Topics

Adult
Autoantibodies
Base Sequence
DNA, Complementary
Female
Fetus
Genes, Immunoglobulin
Humans
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin M
Immunoglobulin Variable Region
Lymphocytes
Molecular Sequence Data
Mutation
Pregnancy

Source

Open in PubMed

Identifiers

PMID: 8228225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8228225-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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