Article
The Cys-67 residue of HLA-B27 influences cell surface stability, peptide specificity, and T-cell antigen presentation.
The Journal of biological chemistry - 28 Dec 2001
Alvarez I, Martí M, Vázquez J, Camafeita E, Ogueta S, López de Castro J A
Abstract excerpt
Cys-67 of HLA-B27 is located in the B pocket, which determines peptide-binding specificity. We analyzed effects of the Cys-67 --> Ser mutation on cell surface expression, peptide specificity, and T-cell recognition of HLA-B*2705. Surface expression was assessed with antibodies recognizing either native or unfolded HLA proteins. Whereas native B*2705 molecules predominated over unfolded ones, this ratio was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.