Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural Alterations

28 Nov 2002

Abstract excerpt

The reasons for the association of the human major histocompatibility complex protein HLA-B27 with spondyloarthropathies are unknown. To uncover the underlying molecular causes, we determined the crystal structures of the disease-associated B*2705 and the nonassociated B*2709 subtypes complexed with the same nonapeptide (GRFAAAIAK). Both differ in only one residue (Asp(116) and His(116), respectively) in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Bullous Skin Diseases
Share to NF-κB Signaling Pathways
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12244049
DOI: 10.1074/jbc.m206392200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural AlterationsPMID 12244049Read ↗

Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptideSemantic proximity Read ↗

Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

Molecular mechanism of the susceptibility difference between HLA-B*27:02/04/05 and HLA-B*27:06/09 to ankylosing spondylitis: substitution analysis, MD simulation, QSAR modelling, and in vitro assay.Semantic proximity Read ↗

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism.Semantic proximity Read ↗

The Peptide Repertoires of HLA-B27 Subtypes Differentially Associated to Spondyloarthropathy (B*2704 and B*2706) Differ by Specific Changes at Three Anchor PositionsSemantic proximity Read ↗

[Subtypes of the HLA-B27 molecule and association with spondylarthropathies].Semantic proximity Read ↗

Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis.Semantic proximity Read ↗

Thermodynamic and Structural Analysis of Peptide- and Allele-dependent Properties of Two HLA-B27 Subtypes Exhibiting Differential Disease AssociationSemantic proximity Read ↗

Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.Semantic proximity Read ↗

A computational docking study on the pH dependence of peptide binding to HLA-B27 sub-types differentially associated with ankylosing spondylitis.Semantic proximity Read ↗

A single residue exchange between two HLA-B27 alleles triggers increased peptide flexibility.Semantic proximity Read ↗

Amino acid signatures in the HLA class II peptide-binding region associated with protection/susceptibility to the severe West Nile Virus diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.