Article
Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703.
European journal of immunology - 1 Aug 1995
Villadangos J A, Galocha B, García F, Albar J P, López de Castro J A
Abstract excerpt
The results in this study address three aspects of peptide binding to the disease-associated antigen HLA-B27 and its modulation by polymorphism: the contribution of major anchor residues 2 and 9, the role of pocket B polymorphism in modulating peptide specificity, and the binding properties of B*2703, a subtype not found to be associated with spondyloarthropathy. Synthetic analogs of peptides naturally presented...
Topics
- Amino Acid Sequence
- Cell Line
- Drug Stability
- HLA-B27 Antigen
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Biosynthesis
- Protein Binding
- Transfection