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Article

Naturally occurring A pocket polymorphism in HLA-B*2703 increases the dependence on an accessory anchor residue at P1 for optimal binding of nonamer peptides.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1997

Griffin T A, Yuan J, Friede T, Stevanovic S, Ariyoshi K, Rowland-Jones S L, Rammensee H G, Colbert R A

Abstract excerpt

Previous studies have shown the B*2703 subtype of HLA-B27, which differs from B*2705 and other MHC class I molecules by having a His substituted for Tyr at position 59 in the A pocket, inefficiently presents certain B*2705-restricted peptides. The current work investigates the influence of the first peptidic amino acid (P1) on peptide binding to B*2705 and B*2703. Results show P1 has a marked effect for both...

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PMID: 9366414

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