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Article

Anchoring pockets in human histocompatibility complex leukocyte antigen (HLA) class I molecules: analysis of the conserved B ("45") pocket of HLA-B27.

The Journal of experimental medicine - 1 Mar 1992

Buxton S E, Benjamin R J, Clayberger C, Parham P, Krensky A M

Abstract excerpt

Dissection of the peptide binding grooves of seven subtypes of human histocompatibility leukocyte antigen (HLA)-B27 into the six specificity pockets defined by the 2.6-A structure of HLA-A*0201 revealed just one pocket, the B ("45") pocket, that is conserved among all the HLA-B27 subtypes. Functional studies of mutant HLA-B*2705 molecules with point substitutions in residues of the B pocket show that this...

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Identifiers

PMID: 1371304
DOI: 10.1084/jem.175.3.809
PMCID: PMC2119159

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