Article
Anchoring pockets in human histocompatibility complex leukocyte antigen (HLA) class I molecules: analysis of the conserved B ("45") pocket of HLA-B27.
The Journal of experimental medicine - 1 Mar 1992
Buxton S E, Benjamin R J, Clayberger C, Parham P, Krensky A M
Abstract excerpt
Dissection of the peptide binding grooves of seven subtypes of human histocompatibility leukocyte antigen (HLA)-B27 into the six specificity pockets defined by the 2.6-A structure of HLA-A*0201 revealed just one pocket, the B ("45") pocket, that is conserved among all the HLA-B27 subtypes. Functi...
Topics
- Amino Acid Sequence
- Epitopes
- HLA-B27 Antigen
- Histocompatibility Antigens Class I
- Humans
- Molecular Sequence Data
- Molecular Structure
- Mutagenesis
- Mutation
- Nucleoproteins
- Orthomyxoviridae
- Peptide Fragments
- Polymorphism, Genetic
- T-Lymphocytes, Cytotoxic