Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein.

doi:10.1016/j.jmb.2005.04.069

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Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein.

Journal of molecular biology - 1 Jul 2005

McFarland Benjamin J, Katz John F, Sant Andrea J, Beeson Craig

Abstract excerpt

The complexity of the interaction between major histocompatibility complex class II (MHC II) proteins and peptide ligands has been revealed through structural studies and crystallographic characterization. Peptides bind through side-chain "anchor" interactions with MHC II pockets and an extensive array of genetically conserved hydrogen bonds to the peptide backbone. Here we quantitatively investigate the kinetic...

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Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein.

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Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein.

Abstract excerpt

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