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Article

Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.

Biochemistry - 26 Nov 1996

Liang M N, Lee C, Xia Y, McConnell H M

Abstract excerpt

We have used molecular modeling to design substitutions in an invariant chain-derived peptide (CLIP), so as to alter the stability of its complex with class II major histocompatibility complex (MHC) proteins. We sought first to test whether CLIP binds in the same way to different class II MHC proteins. We designed destabilizing substitutions of two residues (Met 91 and Met 99) previously predicted to act as the...

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Identifiers

PMID: 8942634
DOI: 10.1021/bi961725b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.PMID 8942634Read ↗

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Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.Semantic proximity Read ↗

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T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein.Semantic proximity Read ↗

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