Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.

doi:10.1021/bi961725b

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Article

Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.

Biochemistry - 26 Nov 1996

Liang M N, Lee C, Xia Y, McConnell H M

Abstract excerpt

We have used molecular modeling to design substitutions in an invariant chain-derived peptide (CLIP), so as to alter the stability of its complex with class II major histocompatibility complex (MHC) proteins. We sought first to test whether CLIP binds in the same way to different class II MHC pro...

Topics

Alleles
Amino Acid Sequence
Animals
Antigens, Differentiation, B-Lymphocyte
Computer Graphics
Histocompatibility Antigens Class II
Kinetics
Major Histocompatibility Complex
Mice
Models, Molecular
Molecular Sequence Data
Protein Binding

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