Article
Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
Colbert R A, Rowland-Jones S L, McMichael A J, Frelinger J A
Abstract excerpt
To investigate the role of an anchoring pocket in allele-specific peptide presentation by a major histocompatibility complex class I molecule, we "transplanted" a B pocket from HLA-A*0201 into HLA-B*2705 by site-directed mutagenesis. The resulting protein, designated B27.A2B, binds a different se...
Topics
- Alleles
- Amino Acid Sequence
- Antigen-Presenting Cells
- Arginine
- Cell Line
- Epitopes
- Genes, MHC Class I
- HLA-B27 Antigen
- Lysine
- Molecular Sequence Data
- Mutation
- Nucleocapsid Proteins
- Nucleoproteins
- Peptide Fragments
- RNA-Binding Proteins