Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding.

Abstract excerpt

Class I major histocompatibility complex molecules play an important role in cellular immunity by presenting antigenic peptides to cytotoxic T cells. Deep polymorphic pockets in the peptide-binding groove of class I major histocompatibility complex molecules provide structural complementarity for peptide "anchor" side chains. However, the minimum requirements of a peptide for high-affinity binding and the...