Article
Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis.
Science (New York, N.Y.) - 24 Jun 1994
Nancarrow J K, Kremer E, Holman K, Eyre H, Doggett N A, Le Paslier D, Callen D F, Sutherland G R, Richards R I
Abstract excerpt
Fragile sites are chemically induced nonstaining gaps in chromosomes. Different fragile sites vary in frequency in the population and in the chemistry of their induction. DNA sequences encompassing and including the rare, autosomal, folate-sensitive fragile site, FRA16A, were isolated by positional cloning. The molecular basis of FRA16A was found to be expansion of a normally polymorphic p(CCG)n repeat. This...
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