Article
Molecular basis for expression of common and rare fragile sites.
Molecular and cellular biology - 1 Oct 2003
Zlotorynski Eitan, Rahat Ayelet, Skaug Jennifer, Ben-Porat Neta, Ozeri Efrat, Hershberg Ruth, Levi Ayala, Scherer Stephen W, Margalit Hanah, Kerem Batsheva
Abstract excerpt
Fragile sites are specific loci that form gaps, constrictions, and breaks on chromosomes exposed to partial replication stress and are rearranged in tumors. Fragile sites are classified as rare or common, depending on their induction and frequency within the population. The molecular basis of rare fragile sites is associated with expanded repeats capable of adopting unusual non-B DNA structures that can perturb...
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