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Article

FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD).

Cancer letters - 8 Feb 2007

Hormozian Fabiola, Schmitt Jens Guido, Sagulenko Evgeny, Schwab Manfred, Savelyeva Larissa

Abstract excerpt

Common fragile sites represent components of normal chromosome structure that are particularly prone to breakage under replication stress. Although the cytogenetic locations of 88 common fragile sites are listed in the Genome database, the DNA at only 14 of them has been defined and characterized at the molecular level. Here, we identify the precise genomic position of the common fragile site FRA1E, mapped to the...

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Source

Identifiers

PMID: 16556484
DOI: 10.1016/j.canlet.2006.02.004

Genes

DPYD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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