Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.

doi:10.1016/j.ygeno.2003.12.017

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.

Genomics - 1 Jul 2004

Sarafidou Theologia, Kahl Christina, Martinez-Garay Isabel, Mangelsdorf Marie, Gesk Stefan, Baker Elizabeth, Kokkinaki Maria, Talley Polly, Maltby Edna L, French Lisa, Harder Lana, Hinzmann Bernd, Nobile Carlo, Richkind Kathy, Finnis Merran, Deloukas Panagiotis, Sutherland Grant R, Kutsche Kerstin, Moschonas Nicholas K, Siebert Reiner, Gécz Jozef

Abstract excerpt

Fragile sites appear visually as nonstaining gaps on chromosomes that are inducible by specific cell culture conditions. Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A. In the present study we have refined the localization of the FRA10A folate-sensitive fragile site by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Fragile Sites

Share to Chromosome Fragility

Share to DNA Methylation

Share to Organ Specificity

Share to Sequence Alignment

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

Open in PubMed

Identifiers

PMID: 15203205
DOI: 10.1016/j.ygeno.2003.12.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.PMID 15203205Read ↗

FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.Semantic proximity Read ↗

The molecular basis of the folate-sensitive fragile site FRA11A at 11q13.Semantic proximity Read ↗

The molecular basis of fragile sites in human chromosomes.Semantic proximity Read ↗

Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis.Semantic proximity Read ↗

Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE.Semantic proximity Read ↗

FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD).Semantic proximity Read ↗

Common Fragile Sites: Genomic Hotspots of DNA Damage and CarcinogenesisSemantic proximity Read ↗

Molecular basis for expression of common and rare fragile sites.Semantic proximity Read ↗

Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus.Semantic proximity Read ↗

<i>C9orf72</i> expansion creates the unstable folate-sensitive fragile site FRA9ASemantic proximity Read ↗

DNA Hypermethylation and Unstable Repeat Diseases: A Paradigm of Transcriptional Silencing to Decipher the Basis of Pathogenic MechanismsSemantic proximity Read ↗

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.