Article
Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus.
Human molecular genetics - 1 Mar 1995
Nancarrow J K, Holman K, Mangelsdorf M, Hori T, Denton M, Sutherland G R, Richards R I
Abstract excerpt
Rare, folate-sensitive fragile sites are the result of the unstable expansion of trinucleotide p(CCG)n repeats, which are normally polymorphic in copy number. Differences in the number and frequency of alleles of the fragile site FRA16A p(CCG)n repeat were observed between different ethnic populations suggesting that certain alleles might be predisposed to instability. Sequence analysis demonstrated that the...
Topics
- Alleles
- Asian People
- Base Sequence
- Chromosome Fragile Sites
- Chromosome Fragility
- Chromosomes, Human
- Female
- Folic Acid
- Gene Frequency
- Humans
- Male
- Models, Genetic