Article
Deletion at fragile sites is a common and early event in Barrett's esophagus.
Molecular cancer research : MCR - 1 Aug 2010
Lai Lisa A, Kostadinov Rumen, Barrett Michael T, Peiffer Daniel A, Pokholok Dimitry, Odze Robert, Sanchez Carissa A, Maley Carlo C, Reid Brian J, Gunderson Kevin L, Rabinovitch Peter S
Abstract excerpt
Barrett's esophagus (BE) is a premalignant intermediate to esophageal adenocarcinoma, which develops in the context of chronic inflammation and exposure to bile and acid. We asked whether there might be common genomic alterations that could be identified as potential clinical biomarker(s) for BE by whole genome profiling. We detected copy number alterations and/or loss of heterozygosity at 56 fragile sites in 20...
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