The molecular basis of fragile sites in human chromosomes.

doi:10.1016/0959-437x(95)80046-8

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Article

The molecular basis of fragile sites in human chromosomes.

Current opinion in genetics & development - 1 Jun 1995

Sutherland G R, Richards R I

Abstract excerpt

Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common...

Topics

Aphidicolin
Chromosome Fragile Sites
Chromosome Fragility
Chromosomes, Human
Culture Techniques
Gene Expression Regulation
Genes
Humans
Mutation
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA

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