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Article

FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.

Molecular cell - 1 May 1998

Hewett D R, Handt O, Hobson L, Mangelsdorf M, Eyre H J, Baker E, Sutherland G R, Schuffenhauer S, Mao J I, Richards R I

Abstract excerpt

A common mechanism for chromosomal fragile site genesis is not yet apparent. Folate-sensitive fragile sites are expanded p(CCG)n repeats that arise from longer normal alleles. Distamycin A or bromodeoxyuridine-inducible fragile site FRA16B is an expanded AT-rich approximately 33 bp repeat; howeve...

Topics

Alleles
Base Sequence
Chromosome Fragile Sites
Chromosome Fragility
Chromosome Mapping
Cloning, Molecular
DNA Mutational Analysis
DNA, Satellite
Family Health
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pedigree

Polymerase Chain Reaction

Polymorphism, Genetic

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 9660961
DOI: 10.1016/s1097-2765(00)80077-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9660961-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.PMID 9660961Read ↗

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