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Article

FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.

Molecular cell - 1 May 1998

Hewett D R, Handt O, Hobson L, Mangelsdorf M, Eyre H J, Baker E, Sutherland G R, Schuffenhauer S, Mao J I, Richards R I

Abstract excerpt

A common mechanism for chromosomal fragile site genesis is not yet apparent. Folate-sensitive fragile sites are expanded p(CCG)n repeats that arise from longer normal alleles. Distamycin A or bromodeoxyuridine-inducible fragile site FRA16B is an expanded AT-rich approximately 33 bp repeat; however, the relationship between normal and fragile site alleles is not known. Here, we report that...

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Identifiers

PMID: 9660961
DOI: 10.1016/s1097-2765(00)80077-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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