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Article

DNA Instability at Chromosomal Fragile Sites in Cancer

27 Jun 2010

Abstract excerpt

Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific translocations containing breakpoints within fragile sites. But until recently, little direct evidence existed...

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PMID: 21286310
DOI: 10.2174/138920210791616699

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