Article
The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest.
The Journal of biological chemistry - 25 Nov 1994
Delphin C, Baudier J
Abstract excerpt
Clone 112 cells, a rat embryo fibroblast cell line cotransfected by an activated ras gene and a temperature-sensitive mutant p53 gene (p53val135) grow well at 37 degrees C but cease DNA synthesis and cell division when shifted to 32 degrees C (Michalovitz, D., Halevy, O., and Oren, M. (1990) Cell...
Topics
- Animals
- Biological Transport
- Cell Division
- Cell Line, Transformed
- Cell Nucleus
- Clone Cells
- DNA-Binding Proteins
- Embryo, Mammalian
- Enzyme Activation
- Fibroblasts
- Genes, ras
- Hot Temperature
- Mutation
- Phosphorylation
- Protein Kinase C
- Rats
- Recombinant Proteins
- Tetradecanoylphorbol Acetate