Article
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.
The EMBO journal - 1 Aug 1995
Donzé O, Jagus R, Koromilas A E, Hershey J W, Sonenberg N
Abstract excerpt
The interferon induced double-stranded RNA-activated kinase, PKR, has been suggested to act as a tumor suppressor since expression of a dominant negative mutant of PKR causes malignant transformation. However, the mechanism of transformation has not been elucidated. PKR phosphorylates translation...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Eukaryotic Initiation Factor-2
- Humans
- Luciferases
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Recombinant Fusion Proteins
- Serine
- Transfection
- eIF-2 Kinase