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Article

Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion.

Oncogene - 18 Apr 1996

Knippschild U, Oren M, Deppert W

Abstract excerpt

We used clone 6 cells (rat embryo fibroblasts transformed by the temperature sensitive mutant p53val135 and an activated H-ras-gene (Michalovitz et al., 1990)), growth arrested at 32 degrees C, as a model to analyse whether and how transformed cells, growth-arrested by an overexpressed wild-type p53, might overcome p53-mediated growth inhibition. When clone 6 cells were kept at 32 degrees C for about 2 weeks,...

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PMID: 8622896

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