Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport.

doi:10.1038/349802a0

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Article

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport.

Nature - 28 Feb 1991

Gannon J V, Lane D P

Abstract excerpt

The p53 protein is rendered temperature-sensitive by a point mutation. Rat cells transformed by this mutant p53 and an activated ras oncogene grow well at 37 degrees C but cease DNA synthesis and cell division when shifted to 32 degrees C. Immunostaining demonstrates that the mutant p53 protein i...

Topics

Animals
Cell Line
Cell Nucleus
Cell Transformation, Neoplastic
Clone Cells
Cycloheximide
DNA Replication
Kinetics
Mutation
Protein Processing, Post-Translational
Rats
Temperature
Tumor Suppressor Protein p53

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