Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.

Molecular and cellular biology - 1 Mar 1991

Hicks G G, Egan S E, Greenberg A H, Mowat M

Abstract excerpt

Overexpression of an activated ras gene in the rat embryo fibroblast line REF52 results in growth arrest at either the G1/S or G2/M boundary of the cell cycle. Both the DNA tumor virus proteins simian virus 40 large T antigen and adenovirus 5 E1a are able to rescue ras induced lethality and cooperate with ras to fully transform REF52 cells. In this report, we present evidence that the wild-type activity of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cloning, Molecular
Share to Gene Expression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, ras

Share to Mutation

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1996096
DOI: 10.1128/mcb.11.3.1344-1352.1991
PMCID: PMC369405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.PMID 1996096Read ↗

The properties of p53 proteins selected for the loss of suppression of transformation.Semantic proximity Read ↗

A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs.Semantic proximity Read ↗

Mammalian cells resistant to tumor suppressor genes.Semantic proximity Read ↗

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.Semantic proximity Read ↗

Genetic mechanisms of tumor suppression by the human p53 gene.Semantic proximity Read ↗

Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein.Semantic proximity Read ↗

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.Semantic proximity Read ↗

Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes.Semantic proximity Read ↗

p53-dependent growth arrest of REF52 cells containing newly amplified DNA.Semantic proximity Read ↗

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.Semantic proximity Read ↗

The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras.Semantic proximity Read ↗

[Mutation of p53 is necessary for stable transformation of REF52 cells by myc+ras oncogenes].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.