Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.

doi:10.1128/mcb.11.3.1344-1352.1991

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Article

Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest.

Molecular and cellular biology - 1 Mar 1991

Hicks G G, Egan S E, Greenberg A H, Mowat M

Abstract excerpt

Overexpression of an activated ras gene in the rat embryo fibroblast line REF52 results in growth arrest at either the G1/S or G2/M boundary of the cell cycle. Both the DNA tumor virus proteins simian virus 40 large T antigen and adenovirus 5 E1a are able to rescue ras induced lethality and coope...

Topics

Animals
Cell Cycle
Cell Line
Cell Transformation, Neoplastic
Cloning, Molecular
Gene Expression
Genes, p53
Genes, ras
Mutation
Proto-Oncogene Proteins p21(ras)
Rats
Transfection

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