Article
Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene.
Molecular microbiology - 1 Nov 1994
Berger K H, Merriam J J, Isberg R R
Abstract excerpt
Legionella pneumophila dot mutations cause defects in intracellular targeting of the microorganism within cultured macrophages. Each of the previously characterized dot mutations was shown to be complemented by a single open reading frame designated dotA. The defects caused by the mutations appea...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Cell Division
- Cell Line
- Cloning, Molecular
- DNA Primers
- DNA, Bacterial
- Genes, Bacterial
- Genetic Complementation Test
- Genetic Linkage
- Humans
- Legionella pneumophila
- Macrophages
- Microscopy, Electron
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation