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Article

Conjugative transfer by the virulence system of Legionella pneumophila.

Science (New York, N.Y.) - 6 Feb 1998

Vogel J P, Andrews H L, Wong S K, Isberg R R

Abstract excerpt

Legionella pneumophila, the causative agent of Legionnaires' pneumonia, replicates within alveolar macrophages by preventing phagosome-lysosome fusion. Here, a large number of mutants called dot (defective for organelle trafficking) that were unable to replicate intracellularly because of an inab...

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Identifiers

PMID: 9452389
DOI: 10.1126/science.279.5352.873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9452389-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conjugative transfer by the virulence system of Legionella pneumophila.PMID 9452389Read ↗

Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion.Semantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.Semantic proximity Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene.Semantic proximity Read ↗

Legionella effectors that promote nonlytic release from protozoa.Semantic proximity Read ↗

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake.Semantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

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