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Article

Conjugative transfer by the virulence system of Legionella pneumophila.

Science (New York, N.Y.) - 6 Feb 1998

Vogel J P, Andrews H L, Wong S K, Isberg R R

Abstract excerpt

Legionella pneumophila, the causative agent of Legionnaires' pneumonia, replicates within alveolar macrophages by preventing phagosome-lysosome fusion. Here, a large number of mutants called dot (defective for organelle trafficking) that were unable to replicate intracellularly because of an inability of the bacteria to alter the endocytic pathway of macrophages were isolated. The dot virulence genes encoded a...

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Identifiers

PMID: 9452389
DOI: 10.1126/science.279.5352.873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conjugative transfer by the virulence system of Legionella pneumophila.PMID 9452389Read ↗

Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion.Semantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.Semantic proximity Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene.Semantic proximity Read ↗

Legionella effectors that promote nonlytic release from protozoa.Semantic proximity Read ↗

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake.Semantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

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