Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.

Molecular microbiology - 1 Jan 1993

Berger K H, Isberg R R

Abstract excerpt

Legionella pneumophila mutants specifically defective for intracellular replication were isolated using an intracellular thymineless death enrichment strategy. Mutants belonging to two distinct phenotypic classes were unable to grow in macrophage-like cultured cells. One class of mutants was defective for both inhibition of phagosome-lysosome fusion and association of host cell organelles with bacteria-containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Transposable Elements
Share to Genes, Bacterial
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysosomes

Share to Macrophages

Share to Mutation

Share to Phenotype

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8382332
DOI: 10.1111/j.1365-2958.1993.tb01092.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.PMID 8382332Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

Analysis of the intracellular fate of Legionella pneumophila mutants.Semantic proximity Read ↗

Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila.Semantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.Semantic proximity Read ↗

Identification of Legionella pneumophila mutants that have aberrant intracellular fates.Semantic proximity Read ↗

Conjugative transfer by the virulence system of Legionella pneumophila.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages.Semantic proximity Read ↗

A genetic screen for Mycobacterium tuberculosis mutants defective for phagosome maturation arrest identifies components of the ESX-1 secretion system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.