Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.

doi:10.1111/j.1365-2958.1993.tb01092.x

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Article

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.

Molecular microbiology - 1 Jan 1993

Berger K H, Isberg R R

Abstract excerpt

Legionella pneumophila mutants specifically defective for intracellular replication were isolated using an intracellular thymineless death enrichment strategy. Mutants belonging to two distinct phenotypic classes were unable to grow in macrophage-like cultured cells. One class of mutants was defe...

Topics

DNA Transposable Elements
Genes, Bacterial
Genetic Complementation Test
Legionella pneumophila
Lysosomes
Macrophages
Membrane Fusion
Mutation
Phagosomes
Phenotype
Tumor Cells, Cultured

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