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Article

The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.

Journal of bacteriology - 1 Mar 2004

Sexton Jessica A, Pinkner Jerome S, Roth Robyn, Heuser John E, Hultgren Scott J, Vogel Joseph P

Abstract excerpt

The ability of Legionella pneumophila to grow and cause disease in the host is completely dependent on a type IV secretion system known as the Dot/Icm complex. This membrane-spanning apparatus translocates effector molecules into host cells in a process that is poorly understood but that is known to require the putative ATPase DotB. One possible role for DotB is suggested by its similarity to the PilT family of...

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Identifiers

PMID: 14996796
DOI: 10.1128/JB.186.6.1658-1666.2004
PMCID: PMC355965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth.PMID 14996796Read ↗

X-ray crystal structures of the type IVb secretion system DotB ATPases.Semantic proximity Read ↗

Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion.Semantic proximity Read ↗

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.Semantic proximity Read ↗

PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus.Semantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus.Semantic proximity Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.Semantic proximity Read ↗

Functional dissection of the three N-terminal general secretory pathway domains and the Walker motifs of the traffic ATPase PilF from Thermus thermophilus.Semantic proximity Read ↗

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