Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.

PLoS pathogens - 1 Sept 2012

Sutherland Molly C, Nguyen Thuy Linh, Tseng Victor, Vogel Joseph P

Abstract excerpt

Legionella pneumophila is a Gram-negative bacterium that replicates within human alveolar macrophages by evasion of the host endocytic pathway through the formation of a replicative vacuole. Generation of this vacuole is dependent upon the secretion of over 275 effector proteins into the host cell via the Dot/Icm type IVB secretion system (T4SS). The type IV coupling protein (T4CP) subcomplex, consisting of DotL,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Bacterial Secretion Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Gene Expression Regulation, Bacterial

Share to Legionella pneumophila

Share to Macrophages

Share to Molecular Chaperones

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 23028312
DOI: 10.1371/journal.ppat.1002910
PMCID: PMC3441705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.PMID 23028312Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.Semantic proximity Read ↗

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

Molecular and structural analysis of Legionella DotI gives insights into an inner membrane complex essential for type IV secretion.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

<i>Legionella</i> translocates an E3 ubiquitin ligase that has multiple U‐boxes with distinct functionsSemantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.Semantic proximity Read ↗

Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of<i>Legionella</i>Intracellular InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.