Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.

Infection and immunity - 1 Oct 2004

VanRheenen Susan M, Duménil Guillaume, Isberg Ralph R

Abstract excerpt

The gram-negative bacterium Legionella pneumophila causes a severe form of pneumonia called Legionnaires' disease, characterized by bacterial replication within alveolar macrophages. Prior to intracellular replication, the vacuole harboring the bacterium must first escape trafficking to the host lysosome, a process that is dependent on the Dot/Icm type IV secretion system. To identify genes required for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Cell Fusion
Share to Endocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endosomes

Share to Legionella pneumophila

Share to Macrophages, Alveolar

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 15385501
DOI: 10.1128/IAI.72.10.5972-5982.2004
PMCID: PMC517542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.PMID 15385501Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Semantic proximity Read ↗

Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for <i>Legionella pneumophila</i> intracellular growthSemantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.Semantic proximity Read ↗

The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.Semantic proximity Read ↗

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.Semantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.Semantic proximity Read ↗

Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of<i>Legionella</i>Intracellular InfectionSemantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

The CpxRA two-component system contributes to Legionella pneumophila virulence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.