Article
Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.
Infection and immunity - 1 Mar 1998
Andrews H L, Vogel J P, Isberg R R
Abstract excerpt
Legionella pneumophila replicates within a specialized phagosome in cultured cells, a function necessary for its pathogenicity. The replicative phagosome lacks membrane marker proteins, such as the glycoprotein LAMP-1, that are indicators of the normal endocytic pathway. We describe the isolation...
Topics
- Animals
- Bacterial Proteins
- Base Sequence
- Cells, Cultured
- Endocytosis
- Female
- Genes, Bacterial
- Genetic Complementation Test
- Genetic Linkage
- Legionella pneumophila
- Macrophages
- Mice
- Molecular Sequence Data
- Mutation
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