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Article

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.

Molecular microbiology - 1 Apr 2003

Conover Gloria M, Derré Isabelle, Vogel Joseph P, Isberg Ralph R

Abstract excerpt

Legionella pneumophila establishes a replication vacuole within phagocytes that requires the bacterial Dot/Icm apparatus for its formation. This apparatus is predicted to translocate effectors into host cells. We hypothesized that some translocated proteins also function to maintain the integrity of the Dot/Icm translocator. Mutations that destroy this function are predicted to result in a Dot/Icm complex that...

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PMID: 12675793
DOI: 10.1046/j.1365-2958.2003.03400.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.PMID 12675793Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

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Legionella effectors that promote nonlytic release from protozoa.Semantic proximity Read ↗

The Legionella IcmSW complex directly interacts with DotL to mediate translocation of adaptor-dependent substrates.Semantic proximity Read ↗

The CpxRA two-component system contributes to Legionella pneumophila virulence.Semantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication.Semantic proximity Read ↗

Conjugative transfer by the virulence system of Legionella pneumophila.Semantic proximity Read ↗

Native structure of a type IV secretion system core complex essential for <i>Legionella</i> pathogenesisSemantic proximity Read ↗

Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system.Semantic proximity Read ↗

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