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Article

Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.

Infection and immunity - 1 Oct 2004

Sexton Jessica A, Miller Jennifer L, Yoneda Aki, Kehl-Fie Thomas E, Vogel Joseph P

Abstract excerpt

Legionella pneumophila utilizes a type IV secretion system (T4SS) encoded by 26 dot/icm genes to replicate inside host cells and cause disease. In contrast to all other L. pneumophila dot/icm genes, dotU and icmF have homologs in a wide variety of gram-negative bacteria, none of which possess a T4SS. Instead, dotU and icmF orthologs are linked to a locus encoding a conserved cluster of proteins designated...

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Identifiers

PMID: 15385502
DOI: 10.1128/IAI.72.10.5983-5992.2004
PMCID: PMC517559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.PMID 15385502Read ↗

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Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila.Semantic proximity Read ↗

Additive effect on intracellular growth by Legionella pneumophila Icm/Dot proteins containing a lipobox motif.Semantic proximity Read ↗

The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.Semantic proximity Read ↗

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