Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2006

Laguna Rita K, Creasey Elizabeth A, Li Zhiru, Valtz Nicole, Isberg Ralph R

Abstract excerpt

Legionella pneumophila requires the Dot/Icm protein translocation system to replicate within host cells as a critical component of Legionnaire's pneumonia. None of the known individual substrates of the translocator have been shown to be essential for intracellular replication. We demonstrate her...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Biological Transport
Share to Flavoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Legionella pneumophila

Share to Macrophages

Share to Mice, Inbred A

Share to Substrate Specificity

Share to Succinate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 17124169
DOI: 10.1073/pnas.0609012103
PMCID: PMC1656969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17124169-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.PMID 17124169Read ↗

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole.Semantic proximity Read ↗

Conjugative transfer by the virulence system of Legionella pneumophila.Semantic proximity Read ↗

Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family.Semantic proximity Read ↗

The Dot/Icm type IV secretion system of Legionella pneumophila is essential for the induction of apoptosis in human macrophages.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

The CpxRA two-component system contributes to Legionella pneumophila virulence.Semantic proximity Read ↗

A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.Semantic proximity Read ↗

Autophagy Evasion and Endoplasmic Reticulum Subversion: The Yin and Yang of<i>Legionella</i>Intracellular InfectionSemantic proximity Read ↗

Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila.Semantic proximity Read ↗

Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.Semantic proximity Read ↗

Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.