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Article

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

Immunity - 1 Jul 1994

Mombaerts P, Anderson S J, Perlmutter R M, Mak T W, Tonegawa S

Abstract excerpt

Expression of the T cell receptor beta (TCR beta) chain is necessary for the transition from the CD4CD8- stage in the major alpha beta thymocyte lineage. The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCR beta locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we...

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Source

Identifiers

PMID: 7889413
DOI: 10.1016/1074-7613(94)90077-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.PMID 7889413Read ↗

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.Semantic proximity Read ↗

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.Semantic proximity Read ↗

Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.Semantic proximity Read ↗

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.Semantic proximity Read ↗

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.Semantic proximity Read ↗

A CD8/Lck transgene is able to drive thymocyte differentiation.Semantic proximity Read ↗

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in miceSemantic proximity Read ↗

Differential requirement for p56lck in fetal and adult thymopoiesis.Semantic proximity Read ↗

The lck paradox: because of inconsistent experimental evidence, the role of the protein tyrosine kinase p56lck in early thymic development remains poorly defined.Semantic proximity Read ↗

A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.Semantic proximity Read ↗

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Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.Semantic proximity Read ↗

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