Article
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
Immunity - 1 Jul 1994
Mombaerts P, Anderson S J, Perlmutter R M, Mak T W, Tonegawa S
Abstract excerpt
Expression of the T cell receptor beta (TCR beta) chain is necessary for the transition from the CD4CD8- stage in the major alpha beta thymocyte lineage. The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCR beta locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Cell Differentiation
- Down-Regulation
- Gene Expression Regulation, Enzymologic
- Homeodomain Proteins
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mice
- Mice, Transgenic
- Mutation