Article
T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.
European journal of immunology - 1 May 1995
Wallace V A, Kawai K, Levelt C N, Kishihara K, Molina T, Timms E, Pircher H, Penninger J, Ohashi P S, Eichmann K
Abstract excerpt
The protein tyrosine kinase, p56lck, is involved in signal transduction in mature T cells and in the molecular events controlling early thymocyte differentiation. Thymuses of mice deficient for p56lck expression (p56lck-/-) consist of immature CD4-CD8- double-negative (DN) and CD4+CD8+ double-positive (DP) thymocytes and are severely reduced in total cell number. In this report we have studied DN thymocytes from...
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Division
- Gene Rearrangement, T-Lymphocyte
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Lymphocytes, Null
- Mice
- Mice, Knockout