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Article

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.

Nature - 7 Oct 1993

Anderson S J, Levin S D, Perlmutter R M

Abstract excerpt

During T-cell development, site-specific DNA rearrangements mediating assembly of beta- and alpha-chain genes of the T-cell receptor (TCR) are developmentally ordered. In particular, assembly and expression of a complete beta-chain gene blocks further rearrangements at the beta-locus (a process referred to as allelic exclusion) and drives the generation and expansion of CD4+8+ cells. Although the mechanism used...

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Identifiers

PMID: 8413611
DOI: 10.1038/365552a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.PMID 8413611Read ↗

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.Semantic proximity Read ↗

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.Semantic proximity Read ↗

Allelic exclusion at the TCRbeta locus.Semantic proximity Read ↗

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.Semantic proximity Read ↗

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Semantic proximity Read ↗

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.Semantic proximity Read ↗

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.Semantic proximity Read ↗

Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.Semantic proximity Read ↗

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.Semantic proximity Read ↗

Receptor-specific allelic exclusion of TCRV alpha-chains during development.Semantic proximity Read ↗

Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.Semantic proximity Read ↗

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