Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.

doi:10.1038/365552a0

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Article

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.

Nature - 7 Oct 1993

Anderson S J, Levin S D, Perlmutter R M

Abstract excerpt

During T-cell development, site-specific DNA rearrangements mediating assembly of beta- and alpha-chain genes of the T-cell receptor (TCR) are developmentally ordered. In particular, assembly and expression of a complete beta-chain gene blocks further rearrangements at the beta-locus (a process r...

Topics

Alleles
Animals
CD4 Antigens
CD8 Antigens
Female
Flow Cytometry
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Hematopoiesis, Extramedullary
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Protein-Tyrosine Kinases

Receptors, Antigen, T-Cell, alpha-beta

Signal Transduction

T-Lymphocyte Subsets

Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 8413611
DOI: 10.1038/365552a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8413611-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes.PMID 8413611Read ↗

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