Article
A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.
Immunity - 1 May 1994
Wayne J, Suh H, Misulovin Z, Sokol K A, Inaba K, Nussenzweig M C
Abstract excerpt
RAG-1 and RAG-2 are developmentally regulated genes that are essential for the assembly of antigen receptors in lymphoid cells. Here we describe transgenic mice that carry RAG-1 and RAG-2 under the control of the proximal lck promoter. Persistent expression of RAG-1 and RAG-2 was associated with...
Topics
- Animals
- Carrier Proteins
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation
- Homeodomain Proteins
- Hyaluronan Receptors
- Immunity, Cellular
- Immunologic Deficiency Syndromes
- Lymphoid Tissue
- Mice
- Mice, Transgenic
- Phenotype
- Promoter Regions, Genetic
- Proteins
- RNA, Messenger
- Receptors, Antigen, T-Cell
- Receptors, Cell Surface