Article
A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development.
Immunity - 1 May 1994
Wayne J, Suh H, Misulovin Z, Sokol K A, Inaba K, Nussenzweig M C
Abstract excerpt
RAG-1 and RAG-2 are developmentally regulated genes that are essential for the assembly of antigen receptors in lymphoid cells. Here we describe transgenic mice that carry RAG-1 and RAG-2 under the control of the proximal lck promoter. Persistent expression of RAG-1 and RAG-2 was associated with incomplete thymopoiesis and profoundly compromised cellular immunity. In addition, RAG transgenic mice rapidly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.