Article
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Nature - 7 Mar 1991
Abraham N, Miceli M C, Parnes J R, Veillette A
Abstract excerpt
Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-mediated aggregation of CD4 (to mimic interaction with its ligand, major histocompatibility complex (MHC) class II molecules), rapidly elevates the kinase activity of...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Histocompatibility Antigens Class II
- Hybridomas
- Insulin
- Lymphocyte Activation
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)