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Article

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.

Nature - 7 Mar 1991

Abraham N, Miceli M C, Parnes J R, Veillette A

Abstract excerpt

Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-mediated aggregation of CD4 (to mimic interaction with its ligand, major histocompatibility complex (MHC) class II molecules), rapidly elevates the kinase activity of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1706070
DOI: 10.1038/350062a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.PMID 1706070Read ↗

Genetic and immunochemical evidence for CD4-dependent association of p56lck with the alpha beta T-cell receptor (TCR): regulation of TCR-induced activation.Semantic proximity Read ↗

The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytes.Semantic proximity Read ↗

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.Semantic proximity Read ↗

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.Semantic proximity Read ↗

Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells.Semantic proximity Read ↗

The role of competing mechanisms on Lck regulation.Semantic proximity Read ↗

Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.Semantic proximity Read ↗

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.Semantic proximity Read ↗

T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.Semantic proximity Read ↗

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.Semantic proximity Read ↗

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.Semantic proximity Read ↗

The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.Semantic proximity Read ↗

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