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Article

Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.

The EMBO journal - 1 Sept 2000

Baker M, Gamble J, Tooze R, Higgins D, Yang F T, O'Brien P C, Coleman N, Pingel S, Turner M, Alexander D R

Abstract excerpt

The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(-/-) background. CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation of the Tyr394 autophosphorylation site. In CD45(-/-)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10970857
DOI: 10.1093/emboj/19.17.4644
PMCID: PMC302076

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SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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