Article
Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.
The EMBO journal - 1 Sept 2000
Baker M, Gamble J, Tooze R, Higgins D, Yang F T, O'Brien P C, Coleman N, Pingel S, Turner M, Alexander D R
Abstract excerpt
The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(-/-) background. CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation of the Tyr394 autophosphorylation site. In CD45(-/-)...
Topics
- Animals
- Apoptosis
- Base Sequence
- DNA Nucleotidyltransferases
- DNA Primers
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Integrases
- Leukemia, T-Cell
- Leukocyte Common Antigens
- Lymphoma, Non-Hodgkin
- Mice
- Mice, Mutant Strains
- Mutation