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Article

A CD8/Lck transgene is able to drive thymocyte differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2006

Fragoso Ruben C, Pyarajan Saiju, Irie Hanna Yoko, Burakoff Steven J

Abstract excerpt

Efficient development of thymocytes requires participation of a CD8 or CD4 coreceptor in the TCR:MHC interaction. Both CD8 and CD4 coreceptor cytoplasmic domains associate with Lck. In this study, we attempted to delineate the role of CD8alpha-associated Lck in driving CD8 single positive (SP) thymocyte development. We used a chimeric molecule encoding the extracellular and transmembrane domains of CD8alpha fused...

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Share to CD8 Antigens
Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Source

Identifiers

PMID: 17056525
DOI: 10.4049/jimmunol.177.9.6007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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