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Article

Differential requirement for p56lck in fetal and adult thymopoiesis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998

Molina T J, Perrot J Y, Penninger J, Ramos A, Audouin J, Briand P, Mak T W, Diebold J

Abstract excerpt

The protein tyrosine kinase p56lck is critical for the generation of mature thymocytes in adult mice. However its requirement during the maturation of thymocytes from the fetal to the adult stage has not been clearly defined. We analyzed prenatal and postnatal thymocyte maturation in mice deficient for p56lck (lck[-/-]). Before birth, lck appears to play a crucial role in the expansion and proliferation of...

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PMID: 9558087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Differential requirement for p56lck in fetal and adult thymopoiesis.PMID 9558087Read ↗

The lck paradox: because of inconsistent experimental evidence, the role of the protein tyrosine kinase p56lck in early thymic development remains poorly defined.Semantic proximity Read ↗

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.Semantic proximity Read ↗

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.Semantic proximity Read ↗

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.Semantic proximity Read ↗

Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.Semantic proximity Read ↗

Age-related changes in p56lck protein levels and phenotypic distribution of T lymphocytes in young rats.Semantic proximity Read ↗

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in miceSemantic proximity Read ↗

A CD8/Lck transgene is able to drive thymocyte differentiation.Semantic proximity Read ↗

Defective expression of p56lck in an infant with severe combined immunodeficiency.Semantic proximity Read ↗

The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.Semantic proximity Read ↗

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.Semantic proximity Read ↗

CDK6 kinase activity is required for thymocyte development.Semantic proximity Read ↗

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