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Article

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.

Science (New York, N.Y.) - 17 Sept 1993

Chan I T, Limmer A, Louie M C, Bullock E D, Fung-Leung W P, Mak T W, Loh D Y

Abstract excerpt

The CD8 alpha cytoplasmic domain associates with p56lck, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8 alpha-Lck association in T cell development was tested with transgenic mice generated to express a CD8 alpha molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8 alpha with Lck. The CD8 alpha mutant was analyzed in a CD8-/-...

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Identifiers

PMID: 8372352
DOI: 10.1126/science.8372352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.PMID 8372352Read ↗

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