Article
Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.
International immunology - 1 May 1998
Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T
Abstract excerpt
The lymphocyte-specific protein tyrosine kinase p56(lck) (Lck) is well documented with regard to its role in regulating T cell activation and thymocyte development through delivery of signals via the mature alphabeta TCR as well as the pre-TCR. Little is known, however, about the role of Lck in Th cell subset differentiation in the periphery. Here, we assess the requirement for tyrosine kinase activation of Lck...
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