Article
Biased utilization of DHQ52 and JH4 gene segments in a human Ig transgenic minilocus is independent of antigenic selection.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1994
Tuaillon N, Miller A B, Longberg N, Tucker P W, Capra J D
Abstract excerpt
We have assessed the effect of antigenic selection on human Ig heavy chain D and JH gene segment utilization in mice that contain transgenes composed of 2 VH (psi VH3-105 and VH5-251), 10 D, 6 JH, C mu, and C gamma 1 human gene segments. Human heavy chains using the functional VH5-251 gene segmen...
Topics
- Animals
- Antigens
- Base Sequence
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Immunoglobulin delta-Chains
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Transcription, Genetic